What is Avanafil

Information about the Avanafil Medicine/Drug:

Avanafil is a phosphodiesterase-5 (PDE5) inhibitor that is used to treat erectile dysfunction. In comparison to other drugs in the same class, it has greater PDE5 selectivity over PDE6 than both sildenafil and vardenafil but less selectivity than tadalafil, indicating a lower risk of visual disturbances associated with off-target PDE6 inhibition.

Avanafil belongs to a class of drugs known as phosphodiesterase (PDE) inhibitors. During sexual stimulation, it increases blood flow to the penis. An erection can result from increased blood flow. Avanafil has no effect on erectile dysfunction or sexual desire. Avanafil has no effect on pregnancy or the spread of sexually transmitted diseases like the human immunodeficiency virus (HIV).

How It works

Avanafil belongs to a class of drugs known as phosphodiesterase (PDE) inhibitors. During sexual stimulation, it increases blood flow to the penis. An erection can result from increased blood flow.


Avanafil is available as a tablet to be taken orally. Avanafil is usually taken with or without food, about 15 minutes before sexual activity, by men taking the 100-mg or 200-mg doses. Avanafil 50 mg is usually taken with or without food as needed, about 30 minutes before sexual activity, by men taking the 50-mg dose. Avanafil should not be taken more than once every 24 hours. Follow the directions on your prescription label exactly, and ask your doctor or pharmacist to explain any parts you don’t understand. Avanafil should be taken exactly as prescribed. Do not take more or less of it, or take it more frequently than your doctor has prescribed.

Your doctor will most likely start you on an average dose of avanafil and may adjust your dose based on how you respond to the medication. Inform your doctor if avanafil isn’t working properly for you or if you experience any side effects.


If you are allergic to avanafil, any other medications, or any of the ingredients in avanafil tablets, tell your doctor and pharmacist. A list of the ingredients is available from your pharmacist or by consulting the patient information.

If you are taking or have recently taken riociguat (Adempas) or nitrates such as isosorbide dinitrate (Dilatrate-SR, Isordil, in BiDil), isosorbide mononitrate (Monoket), or nitroglycerin, do not take avanafil (Minitran, Nitro-Dur, Nitromist, Nitrostat, others). Nitrates are available in the form of tablets, sublingual (under the tongue) tablets, sprays, patches, pastes, and ointments. If you are unsure whether any of your medications contain nitrates, consult your doctor.

While taking avanafil, avoid using nitrate-containing street drugs such as amyl nitrate and butyl nitrate (‘poppers’).

You should be aware that avanafil is only intended for male use. Women should avoid taking avanafil, especially if they are pregnant or may become pregnant, or if they are breastfeeding. If a pregnant woman is taking avanafil, she should contact her doctor.

Consult your doctor about the safe use of alcoholic beverages while taking avanafil. If you consume a large amount of alcohol (more than three glasses of wine or three shots of whiskey) while taking avanafil, you are more likely to experience side effects such as dizziness, headache, rapid heartbeat, and low blood pressure.

Tell your doctor or dentist that you are taking avanafil if you are having surgery, including dental surgery.

Sexual activity can put a strain on your heart, especially if you have heart disease. If you experience chest pain, dizziness, or nausea during sexual activity, contact your doctor immediately and refrain from engaging in sexual activity until your doctor advises you otherwise.

Inform all of your doctors that you are taking avanafil. If you ever require emergency medical treatment for a heart condition, the healthcare providers who treat you will need to know when you last took avanafil.

Disclaimer / Thing to note:

Our goal is to provide you with the most up-to-date and relevant information possible. We cannot, however, guarantee that this list includes all possible dosages because drugs affect each person differently. This information is not intended to be a substitute for professional medical advice. Always consult your doctor or pharmacist about the best dosage for you.

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